* - Contributed equally ✉ - Corresponding Author
Preprints
2024
Principles and Regulation of Mechanosensing
Sala S*, Caillier A*, Oakes PW✉J Cell Sci 137(18):jcs261338 (2024)
PDF | DOI | PMID: 39297391
T cells Use Focal Adhesions to Pull Themselves Through Confined Environments
Caillier A, Oleksyn D, Fowell DJ, Miller J, Oakes PW✉J Cell Biol 223(10):e202310067 (2024)
PDF | DOI | bioRχiv |
Twitter thread | PMID: 38889096
α-catenin middle- and actin-binding domain unfolding mutants differentially impact epithelial strength and sheet migration
Quinn JM, Wang Y, Wood M, Flozak AS, Le PM, Yemelyanov A, Oakes PW, Gottardi CJ✉Mol Biol Cell 35(5):ar65 (2024)
PDF | DOI | bioRχiv | PMID: 38507238
Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly
Quintanilla MA, Patel H, Wu H, Sochacki KA, Chandrasekar S, Akamatsu M, Rotty JD, Korobova F, Bear JE, Taraska JW, Oakes PW✉, Beach JR✉J Cell Biol 223(4):e202305023 (2024)
PDF | DOI | bioRχiv |
Twitter thread | PMID: 38353656- See also: Spotlight: Moonwalking molecular machines: Unraveling the choreography of myosin filament assembly
An interview with Patrick Oakes-Loyola University Chicago, IL, USA
Oakes PW, Trevorrow PCytoskeleton (Hoboken) 81(6-7):287-288, (2024)
PDF | DOI | PMID: 38279969
Machine learning interpretable models of cell mechanics from protein images
Schmitt MS*, Colen J*, Sala S, Devany J, Seetharaman S, Caillier A, Gardel ML✉, Oakes PW✉, Vitelli V✉Cell 187(2):481-494 (2024)
PDF | DOI | arΧiv |
Twitter thread | PMID: 381949652023
Limiting Pool and Actin Architecture Controls Myosin Cluster Sizes in Adherent Cells
Chou W, Molaei M, Wu H, Oakes PW, Beach JR, Gardel ML✉Biophys J, 123(2):157-171 (2023)
PDF | DOI | bioRχiv | PMID: 38062704
Measuring response functions of active materials from data
Molaei M*✉, Redford SA*✉, Chou W, Scheff D, de Pablo JJ, Oakes PW, Gardel ML✉Proc Natl Acad Sci USA, 120(42):e2305283120 (2023)
PDF | DOI | arΧiv | PMID: 37819979
Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells
Wang Y, Troughton LD, Xu F, Chatterjee A, Zhao H, Cifuentes LP, Wagner RB, Chen J, Kuang S, Suter DM, Yuan C, Chan D, Huang F, Oakes PW, Deng Q✉eLife, 12:e88828 (2023)
PDF | DOI | bioRχiv | PMID: 37724949
Shining a Light on RhoA: Optical Control of Cell Contractility
Chandrasekar S, Beach JR, Oakes PW✉Int J Biochem Cell Biol, 161:106442 (2023)
PDF | DOI | PMID: 37348811
Repair of Noise-induced Damage to Stereocilia F-actin Cores is Facilitated by XIRP2 and its Novel Mechanosensor Domain
Wagner EL, Im J-S, Sala S, Nakahata MI, Imbery TE, Li S, Chen D, Nimchuk K, Noy Y, Archer DW, Xu W, Hashisaki G, Avraham KB, Oakes PW, Shin J-S✉eLife, 12:e72681 (2023)
PDF | DOI | bioRχiv | PMID: 37294664
ST3GAL1 and ΒII-spectrin pathways control CAR T cell migration to target tumors
Hong Y*, Walling BL*, Kim H-R, Serratelli WS, Lozada JR, Sailer CJ, Amitrano AM, Lim K, Mongre RK, Kim K-D, Capece T, Lomakina EB, Reilly NS, Vo K, Gerber SA, Fan T-C, Yu AL, Oakes PW, Waugh RE, Jun C-D, Reagan PM, Kim M✉Nat Immunol, 24(6):1007-1019 (2023)
PDF | DOI | PMID: 37069398
Non-muscle myosin 2 filaments are processive in cells
Vitriol EA*✉, Quintanilla MA*, Tidei JJ*, Troughton LD, Cody A, Cisterna BA, Jane ML, Oakes PW✉, Beach JR✉Biophys J, 122(18):3678-3689 (2023)
PDF | DOI | bioRχiv | PMID: 37218133 | Cover Highlight
- See also: Nonmuscle Myosin 2 Keeps on Truckin’ in this Special Issue Dedicated to Ken Jacobson
Quantifying Strain-Sensing Protein Recruitment During Stress Fiber Repair
Seetharaman S*, Sala S*, Gardel ML✉, Oakes PW✉Meth Mol Biol, 2600:169-182 (2023)
PDF | DOI | PMID: 36587097
2021
Meeting report - the ever-fascinating world of septins
Baillet A✉, McMurray MA✉, Oakes PW✉J Cell Sci, 134(24):jcs259552 (2021)
PDF | DOI | PMID: 34910818
A Workflow for Rapid Unbiased Quantification of Fibrillar Feature Alignment in Biological Images
Marcotti S✉, Belo de Freitas D, Troughton LD, Kenny FN, Shaw T, Stramer BM, Oakes PW✉Front Comput Sci, 3:745831 (2021)
PDF | DOI | bioRχiv |
Twitter thread | PMID: 34888522Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA
Sala S, Oakes PW✉Mol Biol Cell, 32(18):1758-1771 (2021)
PDF | DOI | bioRχiv |
Twitter thread | PMID: 340381602020
CD4+ T cell interstitial migration controlled by fibronectin in the inflamed skin
Fernandes NR, Reilly NS, Schrock DC, Hocking DC, Oakes PW, Fowell DJ✉Front Immunol, 11:1501 (2020)
PDF | DOI | PMID: 32793204
TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection
Reilly EC, Lambert-Emo K, Buckley P, Reilly NS, Chaves FA, Yang H, Oakes PW, Topham DJ✉Proc Natl Acad Sci USA, 117(22):12306-12314 (2020)
PDF | DOI | bioRχiv | PMID: 32439709 | Cover Highlight
Optogenetic control of RhoA to probe subcellular mechanochemical circuitry
Cavanaugh KE, Oakes PW, Gardel ML✉Curr Protoc Cell Biol, 86(1):e102 (2020)
PDF | DOI | PMID: 32031760
2019
Multiscale model of integrin adhesion assembly
Bidone TC, Skeeters AV, Oakes PW, Voth GA✉PLoS Comput Biol, 15(6):e1007077 (2019)
PDF | DOI | bioRχiv | PMID: 31163027
Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
Barger SR, Reilly NS, Shutova MS, Li Q, Maiuri P, Heddleston JM, Mooseker MS, Flavell RA, Svitkina T, Oakes PW, Krendel M✉, Gauthier NC✉Nat Commun, 10:1249 (2019)
PDF | DOI | bioRχiv | PMID: 30890704
Tissue tension and not interphase cell shape determines cell division orientation in the Drosophila follicular epithelium
Finegan TM, Na D, Cammarota C, Skeeters AV, Nádasi TJ, Dawney NS, Fletcher A, Oakes PW, Bergstralh DT✉EMBO J, 38(3):e100072 (2019)
PDF | DOI | bioRχiv | PMID: 30478193 | Cover Highlight
- See also: Getting into shape: tissue tension drives oriented cell divisions during organogenesis
- See also: Oriented Cell Division: The Pull of the Pole
2018
Entropy production rate is maximized in non-contractile actomyosin
Seara DS, Yadav V, Linsmeier I, Tabatabai AP, Oakes PW, Tabei SMA, Banerjee S✉, Murrell MP✉Nat Commun, 9:4948 (2018)
PDF | DOI | arΧiv | PMID: 30470750
- See also: Nature Collection on Active Matter
CCR7 fuels and LFA-1 grips
Oakes PW, Fowell DJ✉Nat Immunol, 19(6):516-518 (2018)
PDF | DOI | PMID: 29777210
Balancing forces in migration
Oakes PW✉Curr Opin Cell Biol, 54:43-49 (2018)
PDF | DOI | PMID: 29723736
Lamellipodium is a myosin-independent mechanosensor
Oakes PW✉, Bidone TC, Beckham Y, Skeeters AV, Ramirez-San Juan GR, Winter SP, Voth GA, Gardel ML✉Proc Natl Acad Sci USA, 115(11):2646-2651 (2018)
PDF | DOI | bioRχiv | PMID: 294877208
Dia1-dependent adhesions are required by epithelial tissues to initiate invasion
Fessenden TB, Beckham Y, Perez-Neut M, Chourasia AH, Macleod KF, Oakes PW, Gardel ML✉J Cell Biol, 217(4):1485-1502 (2018)
PDF | DOI | bioRχiv | PMID: 29437785| Cover Highlight
- See also: JCB Journal Club: Formins are required for invasion
- See also: biosights Podcast: April 2, 2018
2017
Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibers
Oakes PW*, Wagner E*, Brand CA, Probst D, Linke M, Schwarz US✉, Glotzer M✉, Gardel ML✉Nat Commun, 8:15817 (2017)
PDF | DOI | bioRχiv | PMID: 28604737
Cholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes
Hissa B, Oakes PW, Pontes B, Ramirez-San Juan GR, Gardel ML✉Sci Rep, 7:43764 (2017)
PDF | DOI | PMID: 28256617
Contact guidance requires spatial control of leading edge protrusion
Ramirez-San Juan GR, Oakes PW, Gardel ML✉Mol Biol Cell, 28(8):1043-1053 (2017)
PDF | DOI | PMID: 28228548
2016
Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility
Linsmeier I, Banerjee S, Oakes PW, Jung W, Kim T, Murrell MP✉Nat Commun, 7:12615 (2016)
PDF | DOI | PMID: 27558758
Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton
Bridges AA, Jentzsch MS, Oakes PW, Occhipinti P, Gladfelter AS✉J Cell Biol, 213(1):23-32 (2016)
PDF | DOI | PMID: 27044896
- See Also: Septins recognize micron-scale membrane curvature
2006-2015
Measuring cell mechanics
Gardel M✉, Oakes P✉Colloquium Series on Quantitative Cell Biology: Vol. 3
Marshall WF, ed. Morgan & Claypool Life Science Publishers. (2015)
PDF | DOI
Forcing cells into shape: the mechanics of actomyosin contractility
Murrell M, Oakes PW, Lenz M, Gardel ML✉Nat Rev Mol Cell Biol, 16(8):486-498 (2015)
PDF | DOI | PMID: 26130009
Model-based traction force microscopy reveals differential tension in cellular actin bundles
Soiné JRD*, Brand CA*, Stricker J, Oakes PW, Gardel ML, Schwarz US✉PLoS Comput Biol, 11(3):e1004076 (2015)
PDF | DOI | PMID: 25748431
Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation
Cetera M*, Ramirez-San Juan GR*, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G, Gardel ML, Horne-Badovinac S✉Nat Commun, 5:5511 (2014)
PDF | DOI | PMID: 25413675
Geometry regulates traction stresses in adherent cells
Oakes PW, Banerjee S, Marchetti CM, Gardel ML✉Biophys J, 107(4):825-833 (2014)
PDF | DOI | PMID: 25140417 | Cover Highlight
- See also: Work and tension: new evidence that adherent cells of same area do the same work independent of stiffness and focal adhesions
Stressing the limits of focal adhesion mechanosensitivity
Oakes PW, Gardel ML✉Curr Opin Cell Biol, 30:68-73 (2014)
PDF | DOI | PMID: 24998185
Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks
Falzone TT, Oakes PW, Sees J, Kovar D, Gardel ML✉Biophys J, 104(8):1709-1719 (2013)
PDF | DOI | PMID: 23601318
Tension is required but not sufficient for focal adhesion maturation without a stress fiber template
Oakes PW*, Beckham Y*, Stricker J, Gardel ML✉J Cell Biol, 196(3):363-374 (2012)
PDF | DOI | PMID: 22291038 | Cover Highlight
- See also: In focus: stress fibers guide focal adhesions to maturity
- Selected for F1000
Spatiotemporal constraints on the force-dependent growth of focal adhesions
Stricker J, Aratyn-Schaus Y, Oakes PW, Gardel ML✉Biophys J, 100(12):2883-93 (2011)
PDF | DOI | PMID: 21689521
Dynamic and structural signatures of lamellar actomyosin force generation
Aratyn-Schaus Y, Oakes PW, Gardel ML✉Mol Biol Cell, 22(8):1330-1339 (2011)
PDF | DOI | PMID: 21307339 | Cover Highlight
- See also: Highlights from MBoC
Preparation of compliant matrices for quantifying cellular contraction
Aratyn-Schaus Y, Oakes PW, Stricker J, Winter SP, Gardel ML✉J Vis Exp, Dec 14 (46) e2173 (2010)
PDF | DOI | PMID: 21178972 | Video
Neutrophil morphology and migration are affected by substrate stiffness
Oakes PW, Patel DC, Morin NA, Zitterbart DP, Fabry B, Reichner JS✉, Tang JXBlood, 114:1387-1395 (2009)
PDF | DOI | PMID:19491394
Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration
Morin NA, Oakes PW, Hyun Y-M, Lee D, Chin EY, King MR, Springer TA, Shimaoka M, Tang JX, Reichner JS, Kim M✉J Exp Med, 205(1):195-205 (2008)
PDF | DOI | PMID:18195072
Growth of tactoidal droplets during the first-order isotropic to nematic phase transition of F-actin
Oakes PW, Viamontes J, Tang JX✉Phys Rev E, 75(6):061902-11 (2007)
PDF | DOI | PMID: 17677295
Isotropic to nematic liquid crystalline phase transition of F-actin varies from continuous to first order
Viamontes J, Oakes PW, Tang JX✉Phys Rev Lett, 97(11):118103 (2006)
PDF | DOI | arΧiv | PMID: 17025933